AmpC Enzyme Mediated by Chromosome Prevailed in Acinetobacter baumannii Strains Isolated from Burned Patients
- VernacularTitle:染色体型AmpC酶在鲍氏不动杆菌烧伤患者分离株中流行
- Author:
Huali CHENG
;
Yuhong PAN
;
Qinghe SU
;
Xuan HUANG
;
Rongfang CHEN
;
Feng ZHANG
- Publication Type:Journal Article
- Keywords:
AmpC enzyme;
Acinetobacter baumannii;
?-Lactamases
- From:
Chinese Journal of Nosocomiology
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the distribation of the AmpC enzyme in Acinetobacter baumannii isolated from burned patients. METHODS Susceptibility tests were used to detect antibiotic resistance to 20 kinds of antimicrobial drugs in 20 strains of A. baumannii isolated from burned patients, AmpC enzyme genes were detected by PCR and partial positive products were chosen to sequence. RESULTS Drug resistances to ?-lactam antibiotics in 20 strains of A. baumannii isolated from burned patients had exceeded 85% except levofloxacin or cefoperazone/sulbactam. Of ADC genes 95% were positive, but all DHA genes were negative. Through sequence and Blast analysis, partial ADC positive products were identical with that of EF546445. CONCLUSIONS The multidrug resistance of A. baumannii isolated from burned patients to ?-lactam antibiotics is serious. AmpC enzyme mediated by chromosome, ADC, prevails in A. baumannii isolated from burned patients.
