Changes of serum inflammatory mediators,lipid profile and left ventricular structure and their correlations in patients with essential hypertension
- VernacularTitle:高血压患者血清炎性递质、血脂及左心室结构的变化及其相关性
- Author:
Jing TAN
;
Qi HUA
;
Rongkun LIU
;
Zheng YANG
- Publication Type:Journal Article
- Keywords:
Hypertension;
Interleukin-6;
Metalloproteinase-9;
Tissue inhibitor of metalloproteinase-1;
Soluble CD40 ligand;
Blood lipid;
Left ventricular structure
- From:
Journal of Medical Postgraduates
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Accumulating evidence shows that hypertension is a chronic low-grade inflammatory disease,and inflammatory reaction is involved in the formation and progress of target-organ damage in hypertension.The authors aimed to explore the changes in the serum levels of interleukin-6(IL-6),soluble CD40 ligand(sCD40L),metalloproteinase-9(MMP-9),tissue inhibitor of metalloproteinase-1(TIMP-1),lipid profile and left ventricular structure in patients with essential hypertension.Methods: The serum levels of IL-6,sCD40L,MMP-9 and TIMP-1,along with blood lipids were determined and echocardiography was performed to evaluate the cardiac structure and function of 158 hypertension patients and 22 age-and sex-matched controls.Results: The hypertension patients exhibited higher levels of IL-6(P
