Progresses on the role of TNF recepetors in the pathogenesis of IBD
- VernacularTitle:肿瘤坏死因子受体与炎性肠病发病机制研究进展
- Author:
Xiaowei WEI
;
Ning LI
;
Weiming ZHU
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor receptor 2;
Pathogenesis;
Different effects;
Inflammatory bowel disease
- From:
Journal of Medical Postgraduates
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
TNF-?,a pleiotropic cytokine with strong proinflammatory and immunomodulatory properties is known to play an important role in inflammatory bowel disease(IBD).The biological effects of TNF-? are elicited by binding to its two cognate recepters,TNFR1 and TNFR2.For a long time,TNF-R1 was considered to be the predominant mediator of TNF-signaling,whereas TNF-R2 was ascribed only auxilliary function.However,there is increasing clinical and experimental evidence for an important independent role of TNF-?/TNFR2 signaling in chronic inflammatory conditions of IBD.The elucidation of the different effects of TNF-signaling in IBD will lead to a better understanding ot the pathogenesis of these diseases and will be the basis for the development of more specific and more efficient therapeutic approaches.
