Effects of photodynamic therapy on microvessels and vascular endothelial growth factor expression in transplanted mouse Heps liver carcinoma
- VernacularTitle:光动力学疗法对小鼠Heps肝癌移植瘤微血管及血管内皮生长因子表达的作用
- Author:
Xin ZHANG
;
Nanzheng ZHANG
- Publication Type:Journal Article
- Keywords:
Photodynamic therapy;
Microvessel;
Vascular endothelial growth factor;
Tumor
- From:
Journal of Medical Postgraduates
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Hitherto there has been no report on the changes of microvessels and the expression of angiogenic factors after photodynamic therapy(PDT) of liver carcinoma.The purpose of this study was to investigate the effect of PDT on the microvessels and the expression of vascular endothelial growth factors(VEGF) in tumor cells. Methods: The mice models subcutaneously transplanted with Heps liver carcinoma were randomly divided into a PDT group(n= 28) and a control group(n= 28).The dynamic changes of the microvessels and VEGF expression in the tumor cells were observed at 2,6,24 and 72 h after PDT by H-E and immunohistochemical staining.Results: Progressive changes were seen in the tumor microvessels at the four time points after PDT,including dilatation,blood stasis,hypostasis,hemorrhage,and angiolysis.Compared with the control group,the microvessel density of the tumors was reduced significantly(P
