Genetic analysis of ?-ADDUCIN and GNB3 in essential hypertension patient
- VernacularTitle:原发性高血压患者?-ADDUCIN和GNB3联合分析
- Author:
Hongye ZHAO
;
Jun CAO
;
Li ZHOU
;
Bin WANG
;
Changchun QIU
- Publication Type:Journal Article
- Keywords:
essential hypetension(EH);
PCR-RFLP;
?-ADDUCIN;
GNB3;
polymorphism
- From:
Basic & Clinical Medicine
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the polymorphism at position G460W of ?-ADDUCIN and at position C825T of GNB3,and the genetic interaction between ?-ADDUCIN and GNB3 genes in a QiQihr essential hypetension population.Methods Three hundreds and thirty-one patients with EH and two hundreds and ninety-three healthy controls were enrolled.Genotyping was performed using PCR-RFLP technique.Results(1)genotype distributions of ?-ADDUCIN G460W(GG 0.177 vs 0.160,GW 0.580 vs 0.481,WW 0.242 vs 0.359,P=0.006) and GNB3(CC0.177 vs 0.353,CT 0.468 vs 0.541,TT 0.355 vs 0.106,P
