Effect of Intravenous Lidocaine on Circulatory Response to Tracheal Intubation .
10.4097/kjae.1991.24.2.373
- Author:
Yoon CHOI
1
;
Seon Hack MOON
;
Seung Woon LIM
Author Information
1. Department of Anesthesiology, Medical College, Gyeongsang National University, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Laryngoscopy;
Endotracheal intubation;
Lidocaine;
Vecuronium;
Noninvasive cardiac output monitor
- MeSH:
Arterial Pressure;
Blood Pressure;
Cardiac Output;
Glycopyrrolate;
Heart;
Heart Rate;
Hemodynamics;
Humans;
Intubation*;
Intubation, Intratracheal;
Laryngoscopy;
Lidocaine*;
Lorazepam;
Lung Diseases;
Ultrasonography;
Vecuronium Bromide
- From:Korean Journal of Anesthesiology
1991;24(2):373-378
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A randomised trial was conducted in 13 patients to assess the circulatory response to endotracheal intubation. None of the patient suffered from heart or lung disease, all were premedicated with lorazepam 0.4 mg/kg, glycopyrrolate 0. 004 mg/kg intramuscularly 30-60 min. beforehand. Patients received vecuronium 0.01mg/kg intravenously for precrurarization and 2 min. later 6 patients received lidocaine 2 mg/kg intravenously and 7 patients received saline 1 ml/20 kg intravenously. Blood pressure and pulse rate were measured repeatedly by an automatic recording device (Datascope 2100A) and cardiac output was measured by noninvasive cardiac output monitor with suprasternal doppler ultrasound. After laryngoscopy and intubation, systolic arterial pressure increased 19.7% mean arterial pressure 18.8% from baseline values in lidocaine group (p<0.05), and systolic arterial pressure increased 21.4% mean artereal pressure 19.8% from baseline values in saline group (p<0. 05). Pulse rate increased 30.9% from baseline values in lidocaine group (p<0.05) and 32.5% from baseline in saline group (p<0.05). But there was no intergroup difference in systolic arterial pressure, mean arterial pressure and pulse rate. Diastolic pressure of both group did not increase significantly and did not show intergroup difference. Cardiac output increased 35.3% from baseline values in lidocaine group (p<0.05). We concluded that lidocaine 2 mg/kg infusion intravenously 2 min prior to laryngoscopy and intubation does not prevent hemodynamic reaction evoked by endotracheal intubation.
