Drug Resistance Investigation of Lower Respiratory Tract Infection with Gram-negative Bacilli in ICU
- VernacularTitle:重症监护病房下呼吸道医院获得性感染革兰阴性杆菌耐药性调查
- Author:
Liang CHEN
;
Dongyuan MA
;
Man ZHANG
- Publication Type:Journal Article
- Keywords:
Intensive care unit(ICU);
Lower respiratory tract;
Hospital acquired infection;
Gram-negative bacilli;
Drug resistance
- From:
Chinese Journal of Nosocomiology
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate flora distribution and drug resistance status of hospital acquired infection with Gramnegative bacilli in lower respiratory tract in intensive care unit(ICU) and to provide the scientific reference for diagnosis and reasonable use of antibiotics.METHODS Referring to National Rules of Procedures in Clinical Laboratory,the strains were isolated.The strains were identified by Identification System of Microscan auto-4. The antibiotic susceptibility test was performed by K-B method and the results were read according to CLSI 2007.RESULTS Among 319 strains of Gram-negative bacilli,the top 4 of isolated rate were Pseudomonas aeruginosa(23.5%),Klebsiella pneumoniae(17.5%),Acinetobacter baumannii(14.4%),and Escherichia coli(14.1%).Severe drug resistance was found in four kinds of important pathogens.Except for 100% susceptibility of Enterobacteriaceae to carbopenems,the drug resistance rate to carbopenems in P.aeruginosa and A.baumannii reached 19.6%-22.7%.Pan-drug resistant strains were found in A.baumannii and P.aeruginosa strains.The detection rate of extensive-spectrum beta-lactamases(ESBLs)-producing K.pneumoniae and E.coli was 39.3% and 42.2%,respectively.CONCLUSIONS The Gram-negative bacilli isolated from lower respiratory tract in hospital acquired infection in ICU are mostly multi-resistant.We should strengthen monitoring and controlling of them.
