Eradication of Haemophilus influenzae in Biofilms in vitro by Moxifloxacin
- VernacularTitle:莫西沙星对流感嗜血菌生物被膜内细菌的清除作用
- Author:
Dong WANG
;
Ying WANG
;
Youning LIU
- Publication Type:Journal Article
- Keywords:
Haemophilus influenzae;
Biofilms;
Moxifloxacin
- From:
Chinese Journal of Nosocomiology
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To determine the activity of moxifloxacin on bacterial biofilms formed by Haemophilus influenzae in vitro.METHODS Formation of bacterial biofilm was examined by crystal violet assay,viable cells counting in biofilms was also carried out.Alterations of biofilms were measured under varying concentrations of moxifloxacin.RESULTS Optical density values of biofilms were significantly decreased at the concentrations higher than 4 mg/L of moxifloxacin.The similar results were obtained for viable cell counting.Bacteria in biofilms were eliminated partly or completely at concentrations higher than 0.25 mg/L.CONCLUSIONS Moxifloxacin is able to destroy the biofilms and reduce viable cells counting at high concentrations.
