Tumorigenicity of human bone marrow mesenchymal stem cells during proliferation in vitro and following differentiation into cardiomyocytes
- VernacularTitle:人骨髓间充质干细胞体外培养增殖过程及分化为心肌样细胞后的致瘤性实验
- Author:
Linye MA
;
Guoyou DAI
;
Yuhao LIU
;
Chuanyu GAO
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).No significant difference was found in c-myc and p16 protein.CONCLUSION:Human BMSCs cultured in vitro in autologous serum meets the requirement of clinic,with enough number,well growth,without karyotype variation,and BMSCs can differentiate into cardiomyocytes.No tumorigenesis is found in body after implantation.Moreover,no significant difference is seen in telomerase activation and c-myc and p16 gene expression.
