Protective effect of Schizandrae Lignanoid on myocardial ischemia-reperfusion injury in hyperlipidemic rats and its mechanism
- VernacularTitle:北五味子总木脂素对高脂血症大鼠心肌缺血再灌注损伤的保护作用及其机制
- Author:
Xiao SUN
;
Enping JIANG
;
Jianguang CHEN
- Publication Type:Journal Article
- Keywords:
Schizandrae Lignanoid;
reperfusion injury;
hyperlipidemia;
rats,Wistar
- From:
Journal of Jilin University(Medicine Edition)
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of Schizandrae Lignanoid (SCL) on myocardial ischemia reperfusion injury in hyperlipidemic rats and its mechanisms and provide theoretical basis and experiment foundation for treatment of myocardial ischemia complicated with hyperlipidemic disease with SCL in the future. Methods After hyperlipidemic rat models were set up by oral administration of high lipid emulsion,the rats were divided into seven groups: control group,sham group,model group,SCL 60,20,5 mg?kg-1 groups and 200 mg?kg-1 CDT group.After reperfusion,the blood samples taken from the ventricles were assayed for blood lipid;MPO activities of ischemic myocardium were measured;Infarct area of left ventricles was measured by Evens blue-TTC staining,and myocardial pathological changes were also observed.Results Compared with model group, the myocardial infarct area/ventricle area ratios and MPO activities in SCL 60,20,5 mg?kg-1 groups decreased (P
