Hardy-Weinberg equilibrium in genetic epidemiology
10.3969/j.issn.1672-7347.2010.01.013
- VernacularTitle:遗传流行病学研究中的H-W平衡检验
- Author:
Hong LIU
;
Yonghua HU
- Publication Type:Journal Article
- Keywords:
Hardy-Weinberg equilibrium;
genetic epidemiology;
association
- From:
Journal of Central South University(Medical Sciences)
2010;35(1):90-封3
- CountryChina
- Language:Chinese
-
Abstract:
Hardy-Weinberg equilibrium test is the base of genetic epidemiology. The new methods for Hardy-Weinberg equilibrium test involve: X chromosome-linked single nucleotide polymorphism Hardy-Weinberg test, inbreeding coefficient(F) test, an incomplete enumeration algorithm for an exact test of Hardy-Weinberg proportions with multiple alleles, and graphical tests for Hardy-Weinberg equilibrium based on the ternary plot. It is necessary to conduct Hardy-Weinberg equilibrium test in genetic epidemiology studies and adjust the associations as deviation of Hardy-Weinberg equilibrium occurs.
