Therapeutic Effects of Different Approaches for Transvaginal Ultrasound-Guided Follicular Aspiration in Infertile Patients with Clomiphene Citrate-Resistant Polycystic Ovary Syndrome
- VernacularTitle:不同卵泡抽吸治疗模式对氯米芬抵抗多囊卵巢综合征的疗效
- Author:
Zhiyi CHEN
;
Weixiang LIANG
;
Kun LIANG
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Infertility;
Ultrasound;
Follicle;
Aspiration
- From:Chinese Journal of Minimally Invasive Surgery
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effectiveness of two different modes of follicular aspiration(FA)guided by transvaginal ultrasound(TVU)in infertile patients with clomiphene citrate(CC)-resistant polycystic ovary syndrome(PCOS).Methods From December 2005 to December 2007,85 patients with CC-resistant PCOS were randomly divided into two groups.Group Ⅰ(thorough treatment)had the every possible small follicles being punctured and aspirated,while group Ⅱ(routine operation)only had the larger follicles being operated.These patients were monitored with TVU and testing the steroid hormone levels.The effect of the two methods on the hormone levels and rates of ovulation and pregnancy were analyzed.Results After the treatments,the cumulative rates of ovulation and pregnancy in the group Ⅰ were higher than those in the group Ⅱ 83.3%(25/30)vs 42.1%(16/38),?2=11.903,P=0.001;43.3%(13/30)vs 13.2%(5/38),?2=7.843,P=0.005].Moreover,the levels of luteinizing hormone(LH)and testosterone(T)were decreased significantly after the treatment in group Ⅰ (17.68?3.11)vs(11.58?1.84),t=9.220,P=0.000;(3.41?2.14)vs(1.47?1.29),t=3.937,P=0.000],whereas those in group Ⅱ were not improved markedly (17.76?4.51)vs(16.11?3.53),t=0.229,P=0.062;(3.88?1.54)vs(3.72?1.27),t=0.995,P=0.326].Conclusions Thorough treatment that has the every possible small follicle being punctured and aspirated can significantly improve the endocrinological abnormalities,and increase the rates of ovulation and pregnancy in patients with CC-resistant PCOS.
