Effects of Ventilation on TNF-? Expression in a Rat Model of Acute Lung Injury
- VernacularTitle:机械通气对急性肺损伤大鼠TNF-?表达的影响
- Author:
Ning CHEN
;
Heling ZHAO
;
Tong CHENG
;
Limin SHEN
;
Yaozong ZHANG
- Publication Type:Journal Article
- Keywords:
Acute lung injury;
Ventilation;
TNF-?
- From:
Chinese Journal of Nosocomiology
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the effect of ventilation on the changes in TNF-? concentration of BALF on acute lung injury model.METHODS Forty healthy male Sprague-Dawley rats were randomly divided into five groups LV,HV,LV2P,LV5P,LV8P and the rat model of acute lung injury was built.Mechanical ventilation was employed in the test groups.Rats were sacrificed after 2 hours ventilation when the serum acquired.The supernatant of BALF was detected for TNF-? concentration.RESULTS The changes in TNF-? content of serum:the TNF-? contentration of serum was higher in HV group than that in LV group(P
