Molecule mechanism of aseptic loosening and drug intervention
- VernacularTitle:人工关节无菌性松动的分子机制及药物干预
- Author:
Liangliang ZHU
;
Jianning ZHAO
- Publication Type:Journal Article
- Keywords:
Ligand of receptoractivator of nuclear factor-?B;
Receptor activator of nuclear factor-?B;
Osteopro tegerin;
Osteolysis;
Drug intervention
- From:
Journal of Medical Postgraduates
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Joint prosthesis is one of the most successful procedures in orthopaedic surgery and has considerably improved the quality of life for patients affected by terminal joint disease. However,a number of joint prosthesis ultimately failed because of aseptic loosening. There have been major advances in the understanding of aseptic loosening. The RANKL-RANK-OPG-NF-?B system has been shown to play a fundamental role in aseptic loosening. We review how the RANKL-RANK-OPG-NF-?B system regulates aseptic loosening and aseptic loosening drug intervention.
