Clinical significance of p27~(Kip1) expression in breast cancer at clinical stage Ⅰ and Ⅱ
- VernacularTitle:Ⅰ、Ⅱ期乳腺癌组织中p27~(Kip1)的表达及其临床意义
- Author:
Weiwei HE
;
Xiaoxiang GUAN
;
Longbang CHEN
- Publication Type:Journal Article
- Keywords:
Early breast cancer;
p27Kip1 expression;
Cytosolic expression;
Clinical feature
- From:
Journal of Medical Postgraduates
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Tumor size,lymphnode metastasis,hormone level and so on have been the prognosis predictors of breast cancer,but they are not ideal. This study is to investigate the influence of the expression of p27Kip1 in early breast cancer prognosis and its relationship with clinical feature. Methods:Archival early breast carcinomas (n=106),were analyzed for p27Kip1 expression by immunohistochemistry EnVision system using specific mono-clonal antibody. Results:The p27Kip1 protein nucleus expression was low in 61 (57.55%) of the 106 cases in early breast carcinomas,which has statistic difference from the high expression in survival rate (P0.05),but correlated with lymph-node metastasis and histological grade (P
