Expression of receptor tyrosine kinase EphA7 in gastric carcinoma and its clinical significances
- VernacularTitle:受体酪氨酸激酶EphA7基因在胃癌中的表达及意义
- Author:
Jiandong WANG
;
Guoli LI
;
Henghui MA
;
Xulin WANG
;
Zheng SHEN
;
Qiu RAO
;
Minhong PAN
;
Zhiyi ZHOU
;
Yingchun DONG
;
Xiaojun ZHOU
- Publication Type:Journal Article
- Keywords:
EphA7;
Receptor tyrosine kinase;
Real-time RT-PCR;
Gastric carcinoma
- From:
Journal of Medical Postgraduates
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Eph is the largest member of the family of receptor tyrosine kinases (RTK). Hypermethylation of CpG island is an important mechanism leading to down-regulation of EphA7 in gastric cancer. The objective of this study is to investigate the expression level of EphA7 in gastric carcinoma and its roles in the development,progression and prognosis of gastric carcinoma. Methods:The expression level of EphA7 transcript in gastric carcinoma specimens and normal mucosa tissues was detected using real-time RT-PCR. Results:The expression level of EphA7 in gastric carcinoma was divided into three groups according to the expression rate in gastric cancer tissue and matched normal mucosa. Statistics analysis showed that the expression of EphA7 is significantly related to age and stage. Overexpression of EphA7 has a tendency to relate to metastasis. Conclusion:EphA7 is differentially expressed in gastric carcinoma specimens. Overexpression of EphA7 may play a role in the development and progress of gastric carcinoma.
