Biological characteristics of MMP and VEGF and their roles in theinfiltration and metastasis of nasopharynx carcinoma
- VernacularTitle:基质金属蛋白酶和血管内皮生成因子的生物学特征及其在鼻咽癌细胞浸润和转移中的作用
- Author:
Xinzheng WU
;
Yingchun HE
;
Daofa TIAN
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinase;
Vascular endothelial growth factor;
Nasopharynx carcinoma;
Infiltration and metastasis
- From:
Journal of Medical Postgraduates
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Researches have indicated that matrix metalloproteinases (MMP) and vascular endothelial growth factors (VEGF) play a key role in the metastasis of nasopharynx carcinoma (NPC). They promote tumor cell infiltration and metastasis by proteolysis of extracellular matrix proteolysis of tumor cells and induction of angiogenesis and lymphangioenesis. Researches on the mechanism of MMPs and VEGFs on NPC may help to further understand the metastasis of NPC and develop new methods for the diagnosis and treatment of NPC and other tumors as well.
