Plasma Lipids and Apolipoproteins as Risk Factor of Ischemic Heart Disease.
10.4070/kcj.1991.21.2.229
- Author:
Shung Chull CHAE
;
Jae Eun JUN
;
Wee Hyun PARK
;
Jung Chul KIM
;
Tai Ho CHUNG
- Publication Type:Original Article
- Keywords:
Lipids;
Apolipoprotein;
Ischemic heart disease
- MeSH:
Angina Pectoris;
Apolipoproteins A*;
Apolipoproteins*;
Cholesterol;
Heart;
Humans;
Immunoelectrophoresis;
Lipoproteins;
Male;
Myocardial Ischemia*;
Plasma*;
Risk Factors*
- From:Korean Circulation Journal
1991;21(2):229-239
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Recent studies suggest that apolipoproteins may be better predictor of ischemic heart disease than are plasma lipids, such as total cholesterol and high density lipoprotein cholesterol(HDL-C). To examine this hypothesis, plasma levels of major lipids and major apolipo-proteins were measured and their derivatives were calculated in 30 male patients with ischemic heart disease(16 angina pectoris and 14 old myocardial infarction) and 30 age-matched male healthy controls. Plasma levels of lipids were obtained by conventional methods and apolipoproteins by Rocket immunoelectrophoresis. Levels of HDL-C, HDL2-cholesterol(HDL2-C), and apolipoprotein-AII, and ratios of HDL-C/total cholesterol, HDL2-C/total cholesterol, and apolipoprotein-AI/apolipoprotein-B were lower in the group of patients than in controls. Levels of low density lipoprotein cholesterol(LDL-C) and apolipoprotein-B, and ratios of lDL-C/HDL-C and apolipoprotein-AI/apolipoprotein-AII were higher in the group of patients. There were no statistically significant differences in the levels of total cholesterol and apolipoprotein-AI between the two groups. Stepwise discriminators analysis showed that apolipoprotein-B and apolipoprotein-AII were better discriminators than plasma lipids for identifying those with ischemic heart disease. One could correctly classify 78% of the cases by using the levels of the two apolipoproteins. By using the level of apolipoprotein-B, one could correctly classify 73% of the cases. There were no correlations between the levels of total cholesterol and HDL-C in the controls whereas there were positive correlations between the levels in the group of patients. In conclusion, this study showed that apolipoprotein-B was the best single discriminator for identifying the patients with ischemic heart disease, followed by apolipoprotein-AII.
