Changes of learning and memory and calmodulin dependent protein kinase Ⅱ expression in hippocampal neurons of pentylenetetrazole-kindled rats
- VernacularTitle:戊四氮点燃癫痫大鼠学习记忆功能及海马神经元钙调素依赖性蛋白激酶Ⅱ表达的变化
- Author:
Yu YIN
;
Wenqing ZHAO
;
Wenling LI
;
Peiyuan L
;
Weibo LI
;
Chuandong LIANG
;
Yuehong WANG
- Publication Type:Journal Article
- Keywords:
epilepsy;
pentylenetetrazole;
hippocmppus;
learning and memory;
calmodulin dependent protein kinaseⅡ
- From:
Basic & Clinical Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of pentylenetetrazole(PTZ)-kindled epliepsy on rat's learning and memory and the expression of calmodulin dependent protein kinaseⅡ(CaMKⅡ)in hippocampal neurons.Methods The rats were injected intraperitoneally with PTZ to establish the kindled models.The changes of behavior were evaluated through Morris water maze and the expression of ?-CaMKⅡ in hippocampal neurons was observed by immunohistochemistry technique.Results The Morris water maze test showed that the escape latency and the swimming distance in PTZ-kindled rats increased significantly(P
