Study on single nucleotide polymorphisms of padi4_94 gene in Chinese Han people of Hebei Province
- VernacularTitle:中国河北地区汉族健康人与RA患者padi4_94单核苷酸多态性的研究
- Author:
Zhongjun FENG
;
Yun LIANG
;
Haifeng WEN
;
Yanli NIU
- Publication Type:Journal Article
- Keywords:
PADI;
single nucleotide polymorphisms;
rheumatoid arthritis
- From:
Chinese Journal of Clinical Laboratory Science
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the gene polymorphism at position padi4_94 in Chinese Han people of Hebei Province and the characters of distribution.Methods 106 healthy individuals and 115 rheumatoid arthritis patients in Hebei Province were randomly selected. Padi4_94 gene was screened by sequencing of the promotor. The correlations between the SNP site and anti-cyclic citrullinated peptide antibody (anti-CCP) was discussed.Results There were three genotypes: AA, AG and GG in Chinese Han people of Hebei Province. No significant differences of gene frequency and allele gene frequency were found between healthy individuals and RA patients, and no correlation between SNP and the production of anti-CCP.Conclusions Hebei Province The gene polymorphisms at position padi4_94 existed in Chinese Han people of Hebei Province,but possibly would not affect RA susceptibility and the production of anti-CCP.
