Drug-resistance and Gene erm Existing in Meticillin-resistant Staphylococcus aureus
- VernacularTitle:耐甲氧西林金黄色葡萄球菌耐药性及erm基因的检测与分析
- Author:
Lifen NING
;
Yuzhen WANG
;
Jiafang ZHANG
;
Xianhou YUAN
- Publication Type:Journal Article
- Keywords:
Meticillin-resistant Staphylococcus aureus(MRSA);
Drug-resistance;
Gene erm
- From:
Chinese Journal of Nosocomiology
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the resistance of meticillin-resistant Staphylococcus aureus(MRSA) and the occurrence of gene erm.METHODS ATB Staph and microdilute tests were performed to detect the susceptibility to 15 kinds of antibiotics in 50 strains of the S.aureus(SAU).Gene erm of these strains was detected by polymerase chain reaction(PCR).RESULTS There were no strains resistant to vancomycin,teicoplanin,fusidic acid and quinupristin-dalfopristin in 42 strains of MRSA detected.There were no strains sensitive to penicillin,oxacillin,gentamicin,tetracycline,ciprofloxacin and levofloxacin.Thirty-five strains habored gene erm in 42 strains of MRSA.The positive rate of gene erm was 83.3%.CONCLUSIONS The multiple-resistance of the MRSA is a serious issue.The resistance to erythromycin in MRSA is mediated by gene erm which encodes the methylase and changes the target site of drug action.
