Risk Factors and Antibiotic Resistance of Lower Respiratory Tract(LRT) Fungal Infection in 76 Hospitalized Patients
- VernacularTitle:76例医院内下呼吸道真菌感染的危险因素与耐药现状分析
- Author:
Yun LIN
;
Ping LIN
;
Jun LIN
- Publication Type:Journal Article
- Keywords:
Fungus;
Lower respiratory tract;
Hospital infection;
Risk factors;
Antibiotic resistance analysis
- From:
Chinese Journal of Nosocomiology
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the main risk factors of fungal infection in lower respiratory tract(LRT) of hospital patients,strains distribution and sensitivity to common antifungal agents so as to provide basis for earlier diagnosis and effective treatment.METHODS Retrospective analysis was taken of the 76 cases with fungal infection in LRT in patients of Taizhou Hospital from Jul 2004 to Jun 2006 based on the diagnostic criteria for nosocomial infections by Ministry of Health of PRC and also following the definition given by European Organization for Research on Treatment of Cancer(EORTC) and us Mycosis study Groap(MSG) in 2002.RESULTS Of the 76 cases,84.2% were over 60 years old.All of them had underlying diseases.Sixty cases had been repeatedly treated with 2 or 5 antibiotics before fungal infection;21 cases received glucocorticoid;6 cases had chemol and radiotherapy and 21 cases underwent invasive treatment procedures.In the three years,77 strains of fungi were isolated from all kinds of samples.Susceptibility testing indicated that the resistance to ketoconazole and miconazole was higher compared with that to fluconacole and itraconazole.CONCLUSIONS Fungal infection in LRT of hospital patients is closely related with age,long stay in hospital,wide administration of broad-spectrum antibiotics,immuno-suppressants and cytotoxic drugs.The most common fungi are Aspergillus and Mucor.There is an increasing number of strains of fungi resistant to drugs,especially to azole antifungal agents.Effective counter measures should be taken without delay.
