Immunology characteristics and application of mesenchymal stem cells in treatment of nephropathy
- VernacularTitle:间充质干细胞免疫学特点及在肾脏疾病中的应用
- Author:
Nanmei LIU
;
Jinyuan ZHANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cells express major histocompability complex (MHC)Ⅰin low levels, but do not express MHC Ⅱ, so it has a low immunogenicity. It can block maturity of dendritic cells, depress immune response of T lymphocytes, and also mediate immune suppression by secreting several soluble cytokines. In light of these characters, mesenchymal stem cell can avoid allograft rejection in human and animal transplantation. It has been reported previously that human mesenchymal stem cells cultivated in growing rodent embryos can grew out of new kidney and ureter. Furthermore, urea nitrogen and creatinine levels were significantly higher in liquid collected from the new ureter compared with the animal serum levels, which suggested that the new kidney had generated urine. This native kidney has low immunogenicity, little side-effect after transplantation, extensive sources, so it may have wide space in self-kidney transplantation.
