Allotransplantation of peripheral blood-derived hemopoietic stem cells for 2 patients with acute leukemia
- VernacularTitle:单倍体外周血干细胞移植治疗急性白血病2例
- Author:
Zhiming WANG
;
Lin WANG
;
Juan MENG
;
Xiansheng LUO
;
Xiaoxia CHEN
;
Qin WU
;
Lili HE
;
Rongxiang FU
;
Yunying WANG
;
Liqiong LI
;
Haimei HUANG
;
Ziying HUANG
;
Lian TAN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Allotransplantation of peripheral blood-derived hemopoietic stem cells is the best therapy for acute leukemia. With increases of only-child families, sibling donors are decreasing. Moreover, the probability is low and time consuming is long to search a matched hemopoietic stem cell donor from the Chinese Marrow Donor Program. Haploidentical stem cell transplantation would bring a hope for donor resource. However, difficult transplantation and high incidence of graft versus host disease are two risks. Based on modified regimen and cyclosporine A+short-term amethopterin, mycophenolic acid, interleukin-11, anti-lymphocyte immunoglobulin and hemopoietic stem cells mobilized by recombinant human granulocyte colony-stimulating factor can prevent graft versus host disease. This therapy succeeded in two cases with no severe graft versus host disease.
