Experimental Study Progress on Tribendimidine,Artemether and Artesuante Against Clonorchis sinensis and other Trematodes
- VernacularTitle:三苯双脒、青蒿琥酯和蒿甲醚抗华支睾吸虫及其他吸虫的实验研究进展
- Author:
Shuhua XIAO
;
Jian XUE
;
Zhongxin WU
- Publication Type:Journal Article
- Keywords:
Clonorchis sinensis;
Trematode;
Tribendimidine;
Artemether;
Artesunate;
Praziquantel
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Currently praziquantel is one of the major drugs used in treatment of schistosomiasis and other trematode infections.Recent experimental studies indicate that a new anthelmintic,tribendimidine,is used in the treatment of intestinal nematodes,also possesses effect against several species of trematodes including Clonorchis sinensis,Opisthorchis viverrini and Echinostoma caproni.Tribendimidine is even more effective against C.sinensis in rats that a single 300 mg/kg oral dose cures almost all of the animals treated,a lower cure dose than praziquantel(375-500 mg/kg).The anti-malarial drugs artemether and artesunate are not only effective in the prevention of schistosomiasis,but also effective against several species of trematodes,especially C.sinensis.The single oral dose of both drugs to cure or achieve high efficacy in infected rats is 75 mg/kg.This review summarized research progress on tribendimidine,artesunate,and artemether in experimental animals infected with C.sinensis and other species of trematodes.
