Protective effect of conjugated linoleic acid on vascular endothelial cells
- VernacularTitle:共轭亚油酸对血管内皮细胞的保护作用
- Author:
Dan YI
;
Guangyou LI
;
Fayi LIU
;
Xiuqin SUN
- Publication Type:Journal Article
- Keywords:
conjugated linoleic acid;
vascular endothelial cells;
saturated fatty acids;
apoptosis
- From:
Chinese Journal of Marine Drugs
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of conjugated linoleic acid(CLA)on survival rate of vascular endothelial cells(VEC).Methods The survival rate of VEC was assessed using MTT method after treating with CLA.Apoptosis and necrosis of the cells were determined using annexin V-propidium iodine double staining.Results CLA significantly increased the cell survival rate to 126.3% after treating for 72h at a dose of 2?mol?L-1,survival in a time-and dose-dependent manner when the concentration was less than 5?mol?L-1.CLA could partly prevent the death of VEC induced by PA and SA.Conclusion CLA can partly prevent the death of VEC induced by PA and SA.The results suggest that CLA are important for the survival of vascular endothelial cells.
