Extended-spectrum ?-Lactamases Production and Antibiotic Resistance in 185 Isolates of Klebsiella pneumoniae
- VernacularTitle:185株临床分离肺炎克雷伯菌中超广谱?-内酰胺酶及耐药性检测
- Author:
Peng WANG
;
Zizhong XIONG
;
Zhongxin WANG
- Publication Type:Journal Article
- Keywords:
Klebsiella pneumoniae;
Extended-spectrum ?-lactamases;
Resistance
- From:
Chinese Journal of Nosocomiology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the prevalence of extended-spectrum ?-lactamases (ESBLs) and antibiotic resistance in Klebsiella pneumoniae isolates.METHODS ESBLs-producers were detected by CLSI phenotypic confirmatory test and susceptibilities were tested by agar dilution method.RESULTS 41.1% Of isolates were ESBLs producers in those isolates. ESBLs producers were highly resistant to piperacillin,cefazolin,cefuroxime,fluoroquinolones,chloramphenicol,SMZ-TMP and amikacin. The resistant rate to piperacillin-tazobactam,and ceftazidime was 26.3% and 34.2%. None was resistant to imipenem and meropenem in ESBLs producers. Except for carbapenems,the resistant rate to other antimicrobial agents was significantly higher in ESBLs producers than non ESBLs producers.CONCLUSIONS With resistance to most of antimicrobial agents,ESBLs-producers are highly prevalent in K. pneumoniae isolates,more attention should be paid to monitor these strains.
