Therapeutic effect of growth hormone, glutamine and optimal diet for patients with short bowel syndrome
- VernacularTitle:生长激素、谷氨酰胺、改良膳食对短肠综合征患者的治疗作用
- Author:
Zhaolin ZENG
;
Qiang CHI
;
Wei PENG
- Publication Type:Journal Article
- Keywords:
Short bowel syndrome;
Growth hormone;
Glutamine;
Parenteral nutrition
- From:
Journal of Medical Postgraduates
2004;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine if growth hormone (GH) and glutamine (Gln) reduce the time and dose of parenteral nutrition (PN) in patients with short bowel syndrome. Methods: Sixteen PN-dependent patients with short bowel syndrome were randomly assigned to Group A (control, oral Gln [0.6 g/kg/d] + GH placebo + diet, n= 5), B (Gln placebo + GH [8 IU/d] + diet, n= 5), and C (Gln + GH + diet, n= 6). PN volume and content were determined by standard criteria based on clinical measurements. After 4 weeks, GH and GH placebo were discontinued, but the diet with Gln or Gln placebo was continued for 12 weeks. Results: Group B showed greater reductions in PN volume, PN calorie and PN frequency than Group A (P
