The changes of the immune function in infants with bronchiolitis and their clinical implication REN
- VernacularTitle:毛细支气管炎患儿免疫功能的变化及临床意义
- Author:
Chunfeng REN
;
Kaixian DU
;
Hongchun LIU
- Publication Type:Journal Article
- Keywords:
Bronchitis;
T lymphocyte subsets;
Immunoglobulins;
Child
- From:
International Journal of Laboratory Medicine
2008;29(9):782-783,786
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of T lymphocyte subsets, immunoglobulin and complements in infants with bronchiolitis and explore the immunopathogenesis of bronchiolitis in in-fants. Methods Sixty-seven infants with bronchiolitis (bronchiolitis group) and forty healthy controls (control group) were enrolled in the study. T lymphocyte subsets were determined by indirected im-munofluorescent assay, and while serum levels of immunoglobulin and complements were determined by timing nephelometry. Results The percentage of CD3+ and CD8+ T cells, the concentrations of se-rum lgA and IgM showed no obvious differences between bronchiolitis group and control group (P>0.05). As compared with those of normal group, the percentage of CD4+ T cells and the ratio of CD4+ to CD8+ were significantly higher (P<0.05 or <0.01) and the levels of serum IgG, C3, C4 were significantly lower in bronchiolitis group(P<0.05 or <0.01). Conclusion Immune function disorder and abnormality occurs in infants with bronchiolitis. T lymphocyte mediated immunity may exert an important antiviral effect. The research from the point of view of cell immunity contributes to evaluation of severity of illness and more effective therapy.
