Mechanism of alleviation of STZ induced pancreatic islets apoptosis by fructose-1,6-disphosphate
- VernacularTitle:1,6二-磷酸果糖减轻STZ致大鼠胰岛细胞凋亡
- Author:
Qian ZHENG
;
Hong LIU
;
Diyong CAO
;
Haitao LAN
;
Hua LIU
;
Haili FANG
;
Neng ZHANG
- Publication Type:Journal Article
- Keywords:
FDP;
STZ;
cell apotosis;
islets cells;
heme oxygenase-1/carbon monoxide;
iNOS/NO;
SOD;
GSH-PX
- From:
Basic & Clinical Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective role of FDP to STZ induced islest apoptosis and the potential mechanisms.Methods The pancreases of the rats were treated to collect islets cells.The cells were incubated with STZ with/or FDP.Cell morphology,insulin secretion,HO-1 activity,CO content,SOD activity,GSH-px activity,iNOS activity were examined.No conetent and apoptotic percentage was detected.Results HO-1 activity and CO content of the normal control group were low.STZ induced a significant decrease of cell activity and insulin release,flow cytometry analysis showed that apoptotic percentage of islet cells remarkably increased following the addition of STZ,FDP obviously improved the islets cellular activity damaged by STZ,basic amount of insulin secretion and stimulated by high glucose were improved(P
