Effects of Levocarnitine on myocardial ischemia in rats
- VernacularTitle:左卡尼汀对大鼠缺血心肌细胞的作用
- Author:
Lijuan CHEN
;
Ying LI
;
Cuiping JING
;
Chunmei HU
- Publication Type:Journal Article
- Keywords:
Levocarnitine;
Trimetazidine Dihydrochloride;
Ischemic myocardium;
Ultrastructure;
Long last calcium channel
- From:
Journal of Medical Postgraduates
2004;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of Levocarnitine preconditionon on the myocardial ultrastructure of ischemic rats and the long last calcium channel. Methods: We randomly divided 30 rats into a control group, a Levocarnitine group and a Dihydrochloride group. After the establishment of ischemic models, we observed the ultrastructure of the ischemic myocardium with optical and transmission electron microscopes, and detected the influx of calcium in the long last calcium channel with the patch clamp. Results: Levocarnitine protected the ultrastructure of ischemic myocardium and inhibited the influx of calcium in the long last calcium channel. Conclusion: Levocarnitine can reduce the severity and extent of ischemia-induced damage to the myocardium, protect mitochondria, stabilize its oxidation, inhibit the long last calcium channel of ischemic ventricular myocytes and lessen the injury induced by calcium overload.
