Effects of sodium phenylbutyrate on invasive ability of human thyroid follicular carcinoma cell line and expression of MMP-9 and TIMP-1
- VernacularTitle:苯丁酸钠对甲状腺滤泡癌细胞侵袭能力及MMP-9和TIMP-1表达的影响
- Author:
Ke SUN
;
Chun LIU
- Publication Type:Journal Article
- Keywords:
sodium phenylbutyrate;
thyroid fallicular carcinoma;
invasion;
metrix metalloproteinase-9(MMP-9);
tissue inhibitor of metalloproteinase-1(TIMP-1)
- From:
Chinese Journal of Cancer Biotherapy
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of sodium phenylbutyrate(NaPB) on the matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-1(TIMP-1) expression and invasive ability of human thyroid follicular carcinoma cell line CGTHW-1.Methods: CGTHW-1 cells were treated with different concentrations of NaPB,then the invasive ability of CGTHW-1 cells was assessed using Transwell assay.The expression of MMP-9 and TIMP-1 was examined by immunocytochemistry staining and RT-PCR in CGTHW-1 cells.Results: After treatment with NaPB(4 mmol/L) for 72 h,CGTHW-1 cells passing the Transwell were significantly reduced[(29.8?1.77) vs(11.00?2.59),P
