Progress in NK cell-based immunotherapy of tumor
- VernacularTitle:基于NK细胞的肿瘤免疫治疗研究进展
- Author:
Zhigang TIAN
- Publication Type:Journal Article
- Keywords:
NK cell;
recognition receptor;
neoplasms;
immunotherapy
- From:
Chinese Journal of Cancer Biotherapy
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The development and differentiation of NK cells are highly noted in recent years.In addition to the peripheral blood,spleen and bone marrow,the liver,lymph nodes and thymus are also considered as important organs for differentiation of NK cell precursors(NKPs).Human NK cell subset CD56bright is enriched in secondary lymphoid tissues and non-lymph tissues;NK subset cell CD56dim can migrate to peripheral inflammatory region.Activating receptors on NK cells include cytokine receptors,integrin receptors,natural cytotoxic receptors,immunoglobulin-like killer receptors,and many new receptors and ligands different from the aforementioned receptor families.In the process of tumor progression,NK cells can directly recognize malignant cells via "internal recognition" and be activated;they can also be activated by accessory cells such as monocytes,macrophages and dentritic cells.DC cells can trigger the activation of NK cells,in which the reverse signal transduction of IL-15R-IL-15 plays an important role.Great progression has been made in NK cell-based immunotherapy of tumor,in particular there are many new ways in NK cell innate recognition-based tumor biotherapy.
