Chloramphenicol Resistance Gene CmlA1 of Shigella:The First Report in China
- VernacularTitle:志贺菌属分离株中发现氯霉素外排泵基因cmlA1
- Author:
Jinyan YE
;
Jianjun ZHU
;
Yuhai DU
;
Hongmei LU
;
Guijun LI
- Publication Type:Journal Article
- Keywords:
Shigella;
Chloramphenicol;
Gene;
Resistance
- From:
Chinese Journal of Nosocomiology
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate mechanisms of chloramphenicol resistance in multi-drug-resistant strains of Shigella.METHODS The strains of multi-resistant Shigella were detected with K-B susceptibility method.The genes(catB,cmlA)of chloramphenicol resistance were detected by polymerase chain reaction(PCR)and the DNA sequencing.RESULTS In 20 strains,the drug-resistance rate of Shigella to chloramphenicol was 70.0%.Two strains carried cmlA but no catB detected was out.The cmlA gene product sequence showed it was cmlA1.CONCLUSIONS The multiple-drug resistante cmlA1 is detected out.This is the first report in China.
