Effect of Rumex.japonicus Houtt extracts on hemopoietic system of model mice with thrombocytopenia
- VernacularTitle:羊蹄根提取物对血小板减少症模型小鼠造血系统的作用
- Author:
Jiankang MA
;
Yanxia JIANG
;
Hongbo MA
;
Xincheng WANG
;
Zhonghang CHEN
;
Juntao LEI
- Publication Type:Journal Article
- Keywords:
Rumex.japonicus Houtt;
thrombocytopenia;
disease model,animal
- From:
Journal of Jilin University(Medicine Edition)
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the treating effect of middle and high doses of acetone and aether extracts from Rumex.Japonicus Houtt on mouse thrombocytopenia.Methods 80 BACB/C mice were randomly divided into 5 groups(n=16): negative control group(salad oil),middle dose(0.5 g?kg-1) and high dose(5 g?kg-1)of acetone and aether extracts groups.All mice in various group were injected with cyclophos-phamide(0.3 mL/20 g) by hypodermic for 3 d to set up the thrombocytopenic model;after mouse thrombocytopenic model was successfully set up,the mice were given salad oil,middle and high doses of acetone and aether extracts,respectively,by gastric perfusion,20 d later the mice were executed,the numbers of the platelet,red cells and white cells were determined.Results ①The numbers of platelet numbers of all groups on the 14th day after making model decreased significantly(P0.05).Conclusion Middle and high doses of acetone and aether extracts have obviously curative effect on mouse thrombocytopenia.
