Clinical and Pathological Value of Serum Hyaluronate Acid, Type Ⅲ Procollagen and Type Ⅳ Procogen for Predicting Liver Fibrosis
- VernacularTitle:血清HA、PC Ⅲ和PC Ⅳ联合检测评估肝纤维化的临床病理价值
- Author:
Hejun YUAN
;
Dechang HU
;
Jiyao WANG
;
Houyu LIU
;
Weirong ZHAI
- Publication Type:Journal Article
- From:
Fudan University Journal of Medical Sciences
2001;28(2):119-120，123
- CountryChina
- Language:Chinese
-
Abstract:
PurposeTo establish sensitive and reliable serum marker on liver fibrosis for early clinical diagnosis. MethodsSerum hyaluronate acid,type Ⅲ procollagen and type Ⅳ procogen of 48 patients with viral hepatitis were analyzed by radioimmunoassay and ELISA respectively. ResultsThe serum HA, PCⅢ and PCⅣ level increased gradually with the progress of the disease. Their levels were correlated distinctly with the index of hepatic activity of inflammation and that of fibrosis.ConclusionsThe value of serum HA,PCⅢ and PCⅣ in predicting liver fibrosis will be enhanced ff the effect of inflammation could be excluded.
