In vitro protoscolicidal effects of hypertonic glucose on protoscolices of hydatid cyst.
10.3347/kjp.2006.44.3.239
- Author:
Seyed Vahid HOSSEINI
1
;
Kurosh GHANBARZADEH
;
Jahra BARZIN
;
Seyed Mahmoud SADJJADI
;
Nader TANIDEH
;
Davood MEHRABANI
Author Information
1. Department of Surgery, Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz 71345-1744, Iran. hoseiniv@sums.ac.ir
- Publication Type:Brief Communication
- Keywords:
Echinococcus granulosus;
hydatid cyst;
protoscolices;
protoscolicidal agents;
hypertonic glucose solution
- MeSH:
Sheep Diseases/*parasitology;
Sheep;
Glucose Solution, Hypertonic/*pharmacology;
Echinococcus granulosus/*drug effects/isolation & purification;
Echinococcosis/*parasitology;
Animals
- From:The Korean Journal of Parasitology
2006;44(3):239-242
- CountryRepublic of Korea
- Language:English
-
Abstract:
To evaluate the protoscolicidal effects of various concentrations of hypertonic glucose, live protoscolices of sheep were exposed to 10%, 15%, 25% and 50% glucose solutions. Cetrimide (0.5%), silver nitrate (0.5%) and hypertonic saline (20%) were used as positive controls, while physiological saline was used as a negative control. After 1, 2 and 5 min, the protoscolicidal effects were determined by 1% eosin. A 25% glucose solution had no significant protoscolicidal effect. However, a 50% glucose solution revealed higher protoscolicidal effect than 0.5% silver nitrate but weaker effect than 0.5% cetrimide; the effect was comparable with that of 20% hypertonic saline. The results showed that hypertonic glucose solution is highly effective in killing protoscolices of Echinococcus granulosus in vitro.
