Organophosphorus pesticide-induced immunotoxicity and its updated mechanisms
- VernacularTitle:有机磷杀虫剂的免疫毒性及其机制的研究进展
- Author:
Qiuyuan XIA
;
Fangqiu LI
- Publication Type:Journal Article
- Keywords:
Organophosphorus pesticide;
Immunotoxicity;
Killer cell;
Granule exocytosis pathway;
FasL/Fas pathway
- From:
Journal of Medical Postgraduates
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Organophosphorus pesticides(OP) are used as insecticides in agriculture throughout the world.The main toxicity of OP is neurotoxicity,which is caused by the inhibition of acetylcholinesterase.OPs also affect the immune response and suppress antibody production,T cell proliferation and the activity of natural killer(NK) cells and cytotoxic T lymphocytes(CTL).However,there have been few studies on the mechanism of OP-induced immunotoxicity,especially the mechanism of OP-induced inhibition of the cytolytic activity of killer cells.This study updates the mechanisms of pesticide-induced immunotoxicity,including its direct and indirect effects on the immune system.
