Strategies for promoting survival,differentiation of stem cells after transplantation and repairing ischemic myocardium
- VernacularTitle:促进移植干细胞存活、分化和修复坏死心肌的策略
- Author:
Xiaojun CUI
;
Yuzhen TAN
;
Haijie WANG
- Publication Type:Journal Article
- Keywords:
stem cell;
survival;
differentiation;
cell transplantation;
cardiac repair
- From:
Basic & Clinical Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The low survival rate of stem cells in the ischemic myocardium microenvironment is the bottle neck in treating ischemic diseases with stem cell transplantation.It is able to increase anti-apoptotic ability of the stem cells and promote their effective differentiation towards myocardial cells directly and indirectly by pretreating the stem cells with cytokines,drugs or chemical compounds,or modifying gene expression to promote cell adhesion,survival or angiogenesis for repairing ischemic myocardium and improving heart function after transplantation of the stem cells.
