Oncogene-induced cellular senenscence
- VernacularTitle:癌基因诱导的细胞衰老
- Author:
Ling ZHAO
;
Zhaohui LU
;
Jie CHEN
- Publication Type:Journal Article
- Keywords:
OIS;
formation of heterochromatin;
DNA-damage checkpoint-response
- From:
Basic & Clinical Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Oncogene-induced senenscence(OIS) is defined as a stable proliferative arrest of normal cells upon overexpression of aberrant proliferative signals of oncogenes through MAPK and PI3K pathway.The molecular mechanism of OIS is related to the formation of heterochromatin and DNA-damage check-point response.The markers of OIS includ senescence-associated ?-galactosidase and senescence-associated heterochromatin foci.With the growing recognization of OIS,the new models of tumor progression are emerging.The further investigation on the mechanism of OIS is of great significance to understanding of the tumorigenesis and provide new ideas and methods of cancer treatment.
