Diagnostic value of connective tissue growth factor for chronic liver disease
- VernacularTitle:血清结缔组织生长因子对慢性肝病的诊断价值
- Author:
Nianyue WANG
;
Dai ZHANG
;
Chengbao YANG
- Publication Type:Journal Article
- Keywords:
connective tissue growth factor;
liver fibrosis;
histopathology;
liver disease
- From:
Chinese Journal of Clinical Laboratory Science
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the connective tissue growth factor(CTGF)in serum and the stages of liver fibrosis of patients with chronic liver disease,and explore new marker for evaluation of liver fibrosis.Methods The serum levels of CTGF in 313 patients with liver disease was detected by ELISA.Hyaluronic acid,type III procollagen,type IV collagen and laminin in serum were determined by RIA.Liver biopsy was performed in 45 patients with chronic liver disease.The quantitative relationship between the levels of CTGF and the stages of liver fibrosis was statistically analyzed by SPSS 11.5 software.Results A positive correlation between the serum levels of CTGF and the severity degree of chronic liver disease was found and the correlation coefficient was strong(r=0.634,P
