Relationship between gene polymorphism of serum amyloid A protein 1 and coronary heart disease
- VernacularTitle:血清淀粉样蛋白A1基因多态性与冠心病的相关性
- Author:
Hongmei YU
;
Xin ZHOU
;
Fang ZHENG
;
Xiying QU
;
Xinli ZHU
- Publication Type:Journal Article
- Keywords:
SAA1;
PCR-RFLP;
coronary heart disease
- From:
Chinese Journal of Clinical Laboratory Science
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the relationship between the gene polymorphism of serum amyloid A protein(SAA)1 and coronary heart disease(CHD).Methods By using PCR-RFLP and sequencing,the gene polymorphism of SAA1 of 183 patients with coronary heart disease and 152 healthy controls were analyzed.Result In the both groups 3 alleles(1.1,1.3,1.5)and 6 genotypes(1.1/1.1,1.1/1.5,1.1/1.3,1.3/1.3,1.3/1.5 and 1.5/1.5)were found.The frequency of 1.5 allele in healthy controls group was notably higher than that in CHD group(P
