Effect of Benidipine-atorvastatin Combination Therapy on Inflammatory Markers and Flow-mediated Dilatation in Elderly Patients with Isolated Systolic Hypertension
- VernacularTitle:贝尼地平与阿托伐他汀联合治疗对老年单纯收缩期高血压患者的抗炎症和改善血管内皮功能的作用
- Author:
Li WANG
;
Ningyuan FANG
;
Tian GAO
;
Haiya WANG
- Publication Type:Journal Article
- Keywords:
Elderly;
Isolated systolic hypertension;
Benidipine;
Atorvastatin
- From:
Chinese Journal of Hypertension
2007;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The effect of combined treatment of statins and calcium channel blockers(CCB) in elderly patients with isolated systolic hypertension(ISH) are not well understood.The purpose of the present study was to assess the additive effect of benidipine-atorvastatin combination therapy in old patients with ISH.Methods Ninety patients with ISH were randomized to receive: placebo(n=15),benidipine treatment(4-8 mg/d,n=25),atorvastatin(20 mg/d,n=25) and benidipine plus atorvastatin treatment(4-8 mg/d+20 mg/d,n=25) for 5 months.Serum concentrations of IL-6,IL-8,hsCRP,flow-mediated dilatation of the brachial artery,urine microalbumin,left ventricular mass index(LVMI),carotid intima-media thickness(CIMT),BP and plasma lipids profiles were examined before and after treatment.Results After 5-months of treatment,the combination treatment significantly reduced IL-6(IL-6 reduction magnitude,combination group: 6.5+6.3 ng/L vs benidipine group: 3.1?3.2 ng/L vs atorvastatin group: 3.3?2.3 ng/L,P
