Correlation of collagen type Ⅱ C-telopeptide to intervertebral disc degeneration and osteoarthritis
- VernacularTitle:Ⅱ型胶原C端肽与椎间盘退变及骨性关节炎的相关性
- Author:
Yongjun WANG
;
Limin WANG
;
Hongjian LIU
;
Zheng XU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: The marker of cartilage degeneration is a hotspot research in recent years. Collagen type II C-telopeptide (CTX-Ⅱ) is a good index which can detect cartilage degeneration through atraumatic method. OBJECTIVE: To observe the correlation of collagen CTX-Ⅱto intervertebral disc degeneration and osteoarthritis. DESIGN, TIME AND SETTING: Retrospective analysis. This subject was completed in the Department of Orthopedics of Zhengzhou University from March to June 2008. PARTICIPANTS: Fifteen patients with intervertebral disc degeneration, including 7 male and 8 female, with mean age of (62?7) years old, and 15 patients with osteoarthritis, containing 6 male and 9 female with mean age of (61?8) years old were selected. In addition, 15 patients (8 male and 7 female) without intervertebral disc degeneration or osteoarthritis, with mean age of (57?6) years old were served as the control group. METHODS: For each patient, fasting second-void morning urine samples were collected and stored at –20 ℃. After all the samples were collected, urinary CTX-Ⅱ was measured by enzyme-link immunosorbent assay. Meanwhile, the creatinine concentrations of each sample were detected for correct the CTX-Ⅱ. MAIN OUTCOME MEASURES: The content and the correlation of urinary CTX-Ⅱ in intervertebral disc degeneration patients and in osteoarthritis patients. RESULTS: A total of 45 patients were included in the final analysis. Compared with the control group, the content of urinary CTX-Ⅱ in intervertebral disc degeneration and osteoarthritis groups were higher, and the distinction had statistical significance (P 0.05). There was positive correlation of urinary CTX-Ⅱ to the grade of intervertebral disc degeneration and osteoarthritis (r=0.592, P=0.003). CONCLUSION: The content of urinary CTX-Ⅱ step up both in intervertebral disc degeneration patients and osteoarthritis patients. Urinary CTX-II has direct correlation with intervertebral disc degeneration and osteoarthritis.
