Significance of proteomics application in regulatory proteins of post-traumatic heterotopic ossification
- VernacularTitle:蛋白质组学在创伤后异位骨化调控蛋白研究中的意义
- Author:
Rongbin LU
;
Jinmin ZHAO
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Heterotopic ossification is the abnormal formation of true bone within extraskeletal soft tissues, which frequently showing a predilection instead for fascia, tendons, and other mesenchymal soft tissues. This paper summarized differential types and quantities of regulatory proteins expression at different stages of heterotopic ossification by proteomics techniques, and screened differential expression of functional proteins at different time points. Further more, identificated and validated certain proteins, which helpful to discovery new regulatory proteins and explore the mutual relationships among the proteins. Proteomics has extensive applications in regulatory proteins research of post-traumatic heterotopic ossification, can further elucidate the mechanism of post-traumatic ectopic bone formation and search for new regulatory biomolecule regulatory sites.
