Directional differentiation of stem cells into islet beta cells: The transplantation for treating diabetes
- VernacularTitle:干细胞移植定向分化为胰岛?细胞治疗糖尿病
- Author:
Xiaohui SUN
;
Yangang WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Mechanism of diabetes is due to damaged ?-cell or absolute or relative lack of insulin caused by insulin resistance. Stem cells have the potential of proliferation and differentiation into insulin-secreting cells, can also solve the problems of immune rejection. Pancreatic stem cells, embryonic stem cells, bone marrow stem cells and cord blood stem cells can be induced to differentiate into ?-cells, or increased ?-cell regeneration using drugs to play a role in diabetes treatment. Stem cell therapy for diabetes research have made progresses, high blood sugar status have been corrected in some of diabetes animals. But islet development and differentiation mechanisms require deeply studies to gain information for embryonic stem cells induced to differentiate into ? cells. A higher differentiation rate and more mature insulin-secreting cells can be achieved using inducible factor with procedures and application.
