Expression of LMP-1,NET-1,and VEGF in non-keratin nasopharyngeal carcinoma and its clinical significance
- VernacularTitle:LMP-1、NET-1、VEGF在非角化性鼻咽癌中的表达及其临床意义
- Author:
Yan WANG
;
Li CHEN
- Publication Type:Journal Article
- Keywords:
non-keratin nasopharyngeal carcinoma(NK-NPC);
latent membrane protein 1(LMP-1);
NET-1;
vascular endothelial growth factor(VEGF);
prognosis
- From:
Chinese Journal of Cancer Biotherapy
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of latent membrane protein-1(LMP-1),NET-1,and vascular endothelial growth factor(VEGF)in non-keratin nasopharyngeal carcinoma(NK-NPC)and its clinical significance.Methods :Sixty biopsy specimens from pathologically-confirmed NK-NPC patients,who were treated in the Affilitated Hospital of Nantong University from May 1999 to May 2003,were included in the present study.Using immunohistochemical techniques (Envison two-step),we examined the expression of LMP-1,NET-1 and VEGF protein in the specimens.The relationship between their expression and elnicopathological parameters and the prognosis was anayzed.Ten specimens of chronic nasopharyngitis served as control.Results:(1)The positive rates of LMP-1,NET-1 and VEGF in NK-NPC were significantly higher than those in the chronic nasopharyngitis(P0.05).(3)NET-1 and VEGF expression in NK-NPC specimens were positively correlated with lymph node metastasis and distant metastasis(P
