In Vitro Observation on Albendazole Sulfoxide and its Enantiomers against Echinococcus granulosus Protoscolex
- VernacularTitle:阿苯达唑亚砜及其对映体体外抗细粒棘球绦虫原头蚴作用
- Author:
Genshu BAO
;
Hong ZHANG
;
Tao JING
;
Hua QIAO
;
Jing WANG
- Publication Type:Journal Article
- Keywords:
Echinococcus granulosus;
Protoscolex;
Albendazole sulfoxide;
Enantiomeric antipode;
In vitro
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate in vitro anti-hydatid efficacy on Echinococcus granulosus protoscolex(EgPSC) by using albendazole sulfoxide(ASOX) and its two enantiomeric antipodes, L-ASOX and D-ASOX.Methods Eg protoscoleces were divided into eight groups and cultured in the DMEM culture media under two concentrations(50 ?g/ml and 100 ?g/ml) of ASOX, L-ASOX and D-ASOX respectively.The appropriate controls included(i) a culture containing an equal amount of DMSO and(ii) a culture medium alone.The mortality of EgPSC in each group was daily counted until 100% EgPSC death in some groups.Results Significant difference of EgPSC mortality was found among the three drugs with various concentrations compared to control group(P0.05), but between ASOX group and L-ASOX group(P
