Spatial Allocation and Specification of Cardiomyocytes during Zebrafish Embryogenesis.
- Author:
Hajime FUKUI
1
;
Ayano CHIBA
;
Takahiro MIYAZAKI
;
Haruko TAKANO
;
Hiroyuki ISHIKAWA
;
Toyonori OMORI
;
Naoki MOCHIUZKI
Author Information
- Publication Type:Review
- Keywords: Embryo development; Cardiac differentiation; Cardiomyocyte; Cardiac progenitor cell; Cilia
- MeSH: Abortion, Spontaneous; Cilia; Embryonic Development*; Embryonic Structures; Female; Germ Layers; Heart; Humans; Myocytes, Cardiac*; Pregnancy; Transcription Factors; Zebrafish*
- From:Korean Circulation Journal 2017;47(2):160-167
- CountryRepublic of Korea
- Language:English
- Abstract: Incomplete development and severe malformation of the heart result in miscarriage of embryos because of its malfunction as a pump for circulation. During cardiogenesis, development of the heart is precisely coordinated by the genetically-primed program that is revealed by the sequential expression of transcription factors. It is important to investigate how spatial allocation of the heart containing cardiomyocytes and other mesoderm-derived cells is determined. In addition, the molecular mechanism underlying cardiomyocyte differentiation still remains elusive. The location of ectoderm-, mesoderm-, and endoderm-derived organs is determined by their initial allocation and subsequent mutual cell-cell interactions or paracrine-based regulation. In the present work, we provide an overview of cardiac development controlled by the germ layers and discuss the points that should be uncovered in future for understanding cardiogenesis.
