Effect of bone marrow mesenchymal stem cells on repairment of carotid artery endothelium injured by balloon in rats
- VernacularTitle:骨髓间充质干细胞对球囊损伤的大鼠颈总动脉内皮修复的影响
- Author:
Yuqiao LI
;
Zhizhong LIU
;
Xiaobo LI
- Publication Type:Journal Article
- Keywords:
Mesenchymal stem cells;
Tunica intima;
Endothelial cells;
Myocytes,smooth muscle
- From:
Chinese Journal of Interventional Cardiology
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of bone marrow mesenchymal stem cells(MSCs) transplation on reparing carotid artery endothelium in S-D rat injured by balloon.Methods Twenty four male Sprague-Dawley(SD) rats underwent balloon overstretch injury in the right common carotid artery and were randomly divided into treatment group(MSCs suspension injected) and control group(phosphate buffered solution injected).Animals were killed to assess vessel morphology and histology at 14 and 28 days after injury in the two groups.Results By H-E staining,morphometric analysis at 14 and 28 days showed that MSCs injection after balloon injury significantly reduced neointimal thickening compared with PBS injection after balloon injury [(0.57?0.06) cm vs(1.09?0.07) cm at 14 days,P